Howard G. Smith, MD, AM
PENTA Medical Network
617-488-9699
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HealthNews RoundUp - 2nd Week of April 2022
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SHORT SHORTS
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Short Shorts for 2nd Week of April, 2022
Vidcast: https://youtu.be/V395dwF4DTs
Short Shorts are quickie reports about cutting edge medical and healthcare discoveries. They’re worth knowing about this 2nd week of April, 2022.
CAR-T chimeric antigen receptors have proven effective immunotherapy for blood system cancers such as leukemias. They haven’t worked as well on solid tumors. Now a Dutch research group working with BioNTech, the developers of the Pfizer CoVid vaccine has found that CAR-T cells kill solid cancers better when they are sensitized to the protein CLDN6 that is found on the surfaces of testicular, ovarian, and endometrial cancer cells. That sensitization can be now accomplished using mRNA. A phase 1 trial of 14 patients with advanced cancers showed a 86% response rate. Very promising.
https://aacr.ent.box.com/s/c5vdgvlj128qojzmuqgwuj2uz8mipqsy
There is a sweet spot for bedtime if you want to have the lowest risk of cardiovascular disease. A UK study of over 88 thousand Brits shows that those hitting the bedsheets between 10 and 11 pm have a 25% lower risk of heart disease compared with those turning in between midnight or later and a 12% lower risk compared with those retiring for the night between 11pm and midnight. These numbers are most statistically significant for women. You’ll have to record your favorite late night talk shows.
University of Pittsburgh developmental biologists have identified a drug cocktail that promises to save the 30% of infants with hypoplastic left heart syndrome who typically die before their first birthdays. One of the drugs in the cocktail is tauroursodeoxycholic acid or TUDCA, used to treat liver disease, and the other is sildenafil, better known as Viagra and used to treat erectile dysfunction. These two drugs together help normalize the defective metabolic processes that otherwise lead to progressive heart failure and death in these babies. The Viagra turns up mitochondrial function in heart muscle cells while the TUDCA prevents the enhanced metabolic activity from overheating these cells. This therapeutic approach could save many infants who cannot get a heart transplant.
The licorice extract glycyrrhizin is a compound that has been used by healers dating back to ancient times for its anti-inflammatory and antioxidant effects. Biomedical scientists at the University of Illinois are now testing it as a therapeutic agent for the prevention and treatment of cancer. The compound also has antiviral effects, and others have tested it as an anti-CoVid drug. Don’t go wolfing down sticks and sticks of licorice though as glycyrrhizin can raise your blood pressure to dangerously high levels.
https://www.sciencedirect.com/science/article/pii/S1043661822000834?via%3Dihub#!
There you have the latest reveals for the 2nd week of April, 2022. When additional information about these developments becomes available, I’ll pass it on to you.
#CAR-T # CLDN6 #bioNtech #bedtime #cardiovascular #hypoplasticleftheart #sildenafil #viagra #tudca #licorice #cancer #covid
CAR-T, CLDN6, bioNtech, bedtime, cardiovascular, hypoplasticleftheart, sildenafil, viagra, tudca, licorice, cancer, covid
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CPSC Recalls
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biOrigins Sodium Hydroxide Product Packaged Improperly
Vidcast: https://youtu.be/WLLraWCVLIY
The CPSC and the Madar Corporation are recalling biOrigins Sodium Hydroxide Product. This product contains the caustic lye sodium hydroxide and must be sold in child-resistant packaging in order to prevent the possibility of chemical burns of the skin, eyes, and, if ingested, the mouth, throat, and gastrointestinal tract. Thirty packages of this extremely dangerous material were sold via amazon.com. If you have this products at home, immediately store it out of reach of children. Contact the Madar Corporation by with a collect phone call at 1-315-537-8102 or via the email pat@madarcorporation.co.uk in order to obtain a full refund and a warning label to place on the package. I would store this material in a lockage container.
#biorigins #naoh #sodiumhydroxide #lye #caustic #burns #children #recall
biorigins, naoh, sodiumhydroxide, lye, caustic, burns, children, recall
Bestar Wall Beds Can Crash Down
Vidcast: https://youtu.be/jtJXptWBhMw
The CPSC and Bestar are now recalling Bestar Wall Beds. These Murphy-style beds may detach from the wall and come crashing down on those nearby leading to serious crush injuries or death. The models involved in the recall include: the Nebula, PUR, Versatile, Edge, Cielo, Audrea, Lumina, Orion, and the Novello Full and Queen Wall Beds. About 129,000 of these beds were sold in the US and about 53,000 were sold in Canada online at Wayfair.com, Costco.com, Cymax.com, and Amazon.com. If you have a Bestar wall bed, contact Bestar at 1-888-912-8458 or via email at Bestar8577@stericycle.com to find out if your bed requires a repair. Bestar will arrange for a free inspection and a reinstallation if necessary.
#bestar #wallbed #detachment #crush #injury #death #recall
bestar, wallbed, detachment, crush, injury, death, recall
Clikk High Chairs Have Defective Seats
Vidcast: https://youtu.be/XO7Zs_avJDM
The CPSC and Stokke now recall Clikk High Chairs. The white plastic seats on these units may break creating a risk of fall and injury hazards to those children using them. About 790 units were sold in the US and 48 were sold in Canada at Target, Buy Buy Baby, and other children’s stores nationwide and online at www.stokke.com and www.amazon.com. If you bought one of these high chairs, stop using it. Contact Stokke by phone at 1-877-978-6553 or via email at info-usa@stokke.com for a free replacement.
https://www.cpsc.gov/Recalls/2022/Stokke-Recalls-Clikk-High-Chairs-Due-to-Fall-and-Injury-Hazards
#clikk #highchair #children #seat #fall #injury #recall
clikk, highchair, children, seat, fall, injury, recall
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FDA Recalls
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Kinder Happy Moments Milk Chocolate and Crispy Wafers Assortments & Mix Chocolate Treats Baskets on Recall
Vidcast: https://youtu.be/Ghlw9p02c-c
The FDA and Ferrero USA, Inc.are recalling Kinder Happy Moments Milk Chocolate and Crispy Wafers Assortments & Mix Chocolate Treats Baskets. These products are contaminated with salmonella. This bacterium can cause serious and life-threatening infections in the very young, elders, and in those with a suboptimal immune response. If you purchased these products, do not consume them and sequester them from your children. Call the Ferrero customer service line at 1-800-688-3552 to arrange a full refund.
#ferraro #kinder #chocolate #salmonella #infection #recall
ferraro, kinder, chocolate, salmonella, infection, recall
Carbquik Double Chocolate Chunk Mug Cakes on Recall
Vidcast: https://youtu.be/iQz-e628NZc
The FDA and Tova Industries, LLC are recalling Carbquik Double Chocolate Chunk Mug Cakes. This product contains undeclared milk. Those with a milk allergy could develop a serious or life-threatening allergic reaction after ingesting this product. The recalled packs are lot #02212071B with a sell by date of July 26, 2022. If you have this product and you or a family member have a milk allergy, call the company at 1-502-267-7333 to arrange a refund. Then destroy the product.
#carbquik #chocolate #milk #allergy #recall
carbquik, chocolate, milk, allergy, recall
Recalled is Whole Foods Market 365 Organic Creamy Caesar Dressing
Vidcast: https://youtu.be/02KeFg7mVRc
The FDA and Van Law Food Products, Inc. are recalling Whole Foods Market 365 Organic Creamy Caesar Dressing. This salad dressing contains undeclared wheat and soy allergens. Those allergic to wheat or soy or have a gluten problem, particularly those with celiac disease may develop a severe or life-threatening allergic reaction after ingesting this caesar salad dressing. The lot involved has a best by date of 11/17/22 and was sold in Arkansas, Connecticut, Louisiana, Massachusetts, Maine, New Jersey, Oklahoma, Rhode Island, New York, Texas, and New Hampshire. If you bought this product, you may return it to your Whole Foods Store with a receipt for a full refund. For more information, call Van Law Food Products at 1-714-578-3134.
#wholefoods #365 #caesardressing #soy #wheat #gluten #celiac #allergy #recall
wholefoods, 365, caesardressing, soy, wheat, gluten, celiac, allergy, recall
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