Howard G. Smith, MD, AM
PENTA Medical Network
617-488-9699
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HealthNews RoundUp - 3rd Week of April 2021
=========================
Medicine of The Future - 3wkApril2021
Vidcast: https://youtu.be/_HW1iHftI3o
New developments for:
Skin Cancer, Pancreatic Cancer, Stroke, Pediatric Heart Disease, Male Contraception, Genetic Engineering
All this on Medicine of the Future.
Researchers at the Ohio State Comprehensive Cancer Center suggest that the already available and inexpensive neurodrug dopamine can reduce the development of common skin cancers including basal cell and squamous cell carcinomas. Testing this drug in mice, it stimulates receptors in the cell that block the cancer-inducing effects of ultraviolet light. The drug could be a godsend for those with light-complexions and a propensity for skin cancer
University of Pennsylvania oncologists report a preliminary phase 1 study of a drug that drives killer T cells into notoriously treatment-resistant pancreatic cancer. The drug selicrelumab was given to 15 patients before their surgery and chemotherapy. The excised tumor specimens were T-cell enriched and less fibrotic permitting better penetration of other therapeutic agents. The treated group lived nearly twice as long.
mRNA delivered to brain tissues can induce an agent that protects during a stroke. Tokyo neuroscientists and bioengineers developed mRNA in a polymer nanoball that codes for BDNF, brain-derived neurotrophic factor, that enhances the survival of neurons deprived of oxygen during a stroke. The best news is that the mRNA treatment works well even if given 2 to 5 days after the neuro-catastrophic stroke.
University of Minnesota bioengineers have created pediatric heart valve replacements that can grow with their young recipients. The researchers constructed valved conduits made from fibroblast-derived collagen that grew with the recipient lambs. These valves revealed good function up to a year after implantation and developed less calcification than conventional bioprosthetic valves.
A Chinese herbal compound, triptonide, given orally can reduce sperm motility producing consistent yet reversible male infertility after 6 weeks of therapy. Collaborators at the University of Nevada and UCLA developed and tested this compound which may well be the first practical non-hormonal male contraceptive. Triptonide blocks the last steps of sperm assembly and may be purified from the Chinese herb or directly synthesized.
Wearable technology is on the rise, and many smart sensors may require wearable antennas to transmit that data for processing. Such antennas must be able to twist, compress, and stretch. Bioengineers at Penn State in collaboration with China’s Hebei University of Technology have now developed a layered copper mesh antenna with transmission properties minimally affected by geometric changes.
Genetic engineering, the ability to treat diseases by modifying a human’s cellular genetic makeup takes two giant steps forward. First…….Geneticists at UC-San Francisco announce a modification to the epic CRISPR-CAS genetic editing technique that permits controlling expression of given genes without modifying the core cellular DNA. This technique, called CRISPRoff, can modify epigenetic material in the nucleus that silences a gene and prevents its production of proteins. This change is inherited.
In a second development……..As useful as CRISPR-CAS gene editing may be, Carnegie Mellon biochemists announce a new peptide nucleic acid-based or PNA-based system that does what CRISPR can’t. PNA editing can modify cells in a living animal while CRISPR edits cells removed from the body. The PNA-donor DNA in a nanoparticle package can’t modify as many cells at one time as CRISPR, but it appears more precise with fewer off-target DNA modifications.
These and other cutting edge solutions are coming to your doctor’s office and our hospitals…….some day soon!
https://cancerpreventionresearch.aacrjournals.org/content/early/2021/04/08/1940-6207.CAPR-21-0052
https://www.sciencedaily.com/releases/2021/04/210411114048.htm
https://stm.sciencemag.org/content/13/585/eabb7225
https://www.nature.com/articles/s41467-021-21517-5
https://www.sciencedirect.com/science/article/abs/pii/S0142961221000326?via%3Dihub
https://www.sciencedirect.com/science/article/pii/S0264127521002732?via%3Dihub
https://www.nature.com/articles/s41586-021-03191-1
#SkinCancer #PancreaticCancer #Stroke #PediatricHeartDisease #MaleContraception #GeneticEngineering
SkinCancer, PancreaticCancer, Stroke, PediatricHeartDisease, MaleContraception, GeneticEngineering
Medicine of The Future - 3wkApril2021. #SkinCancer #PancreaticCancer #Stroke #PediatricHeartDisease #MaleContraception #GeneticEngineering. 5 of 5
Weight Extremes Trigger Recurrent Miscarriages
Vidcast: https://youtu.be/psC1lsiDV8k
Being overweight but also underweight boosts a woman’s risk of suffering recurrent pregnancy losses by 20%. British obstetricians performed a focused meta-analysis of 16 published studies covering nearly 66,000 women.
Repeated miscarriages are 21% more likely in women with BMI’s >25 than those with normal body weight. In those with repeated losses, having a BMI greater than 30 bumps up the risk of additional miscarriages to 77%. Those with BMIs under 18, were 20% more likely to have repeat losses, particularly if they were underweight between the ages of 18 and 20.
Smoking, drinking, coffee, stress, and night shifts had no significant effects on recurrent miscarriages.
Pregnant women should weigh daily and adjust intake accordingly.
https://www.nature.com/articles/s41598-021-86445-2
#miscarriage #overweight #underweight
miscarriage, overweight, underweight
CoVid Often Recurs In Young Adults
Vidcast: https://youtu.be/2RYVDOo7gA8
If you had CoVid, there is still a 1 in 10 chance of reinfection. Researchers at New York’s Mount Sinai Hospital followed 2,346 predominately male Marines 18-20 years of age over a 6 month study period. Those entering the study with CoVid antibodies were considered to have been infected.
Ten percent became reinfected. The reinfected had significantly lower anti-CoVid antibody levels as the result of their first infections. The reinfected were predominately (84%) asymptomatic, but they harbored sufficient virus to infect others.
Even if you had CoVid, get the vaccine since your natural infection produces insufficient protective antibodies. Studies show that you need only a single dose.
https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(21)00158-2/fulltext
#CoVid #reinfection #antibodies #vaccine
CoVid, reinfection, antibodies, vaccine
CoVid Itself Causes More Brain Clots Than Vaccine
Vidcast: https://youtu.be/Qz4DYKCooz4
A CoVid infection is 8 times more likely to be associated with blood clots in the brain than vaccination with the AstraZeneca vaccine. This from studies by the European Medicines Agency and British neuroscientists.
Cerebral venous thrombosis occurs in 39 per million with CoVid infection but in only 5 per million after the AstraZeneca vaccine or 4.1 per million after an mRNA vaccine. Fifty percent of brain clots occur in those under 40. Only 20% occurred in the 40-59 groups, and 15% in each of the 60-69 and 70-79 age groups.
CoVid itself carries a greater risk of devastating brain clots than do any of the currently approved vaccines.
#thrombosis #CoVid #vaccines
thrombosis, CoVid, vaccines
Specific Blood Pressure Drugs Associated With Skin Cancer
Vid https://youtu.be/DDmhbn0MY8k
Thiazide blood pressure drugs including hydrochlorthazide can bump up the risk of deadly skin cancer by 60%. This the conclusion from a University of Toronto study comparing 302,634 adults on hypertensive medications and 605, 268 unmedicated matched controls.
Increasing doses of thiazide medications were associated with increasing incidence of melanoma and the less lethal keratinocyte carcinoma. On the whole those on this medication had a 60% higher incidence of melanoma, a 52% higher incidence of advanced keratinocyte carcinoma, and a 44% increased rate of keratinocyte carcinoma.
Those with light, sensitive skin prone to cancer should use another blood pressure med. Those on thiazides should have their skin checked carefully by a dermatologist.
https://www.cmaj.ca/content/193/15/E508
#thiazide #hydrochlorthiazide #melanoma #skincancer #hypertension
thiazide, hydrochlorthiazide, melanoma, skincancer, hypertension
Speed Bumps A Danger For Pregnancies
Vidcast: https://youtu.be/HVYYr5Ilqd8
Hitting speed bumps at speeds exceeding 28 mph may cause brain injuries to a 3rd trimester fetus and uterine stress for the mother. This warning comes from engineers at the University of British Columbia.
The investigators derived their conclusions from models that calculate the effects of speed bump shear on the fetal brain as well as the uterus after a vehicle hits the bump. Variables include the vehicle speed and the speed bump size.
Crunching the numbers leads to the conclusion that vehicles with women in their late pregnancy stages should go over speed bumps at 15 mph or less. They similarly caution care and suggest slower speeds when traversing bumpy terrain.
https://www.sciencedirect.com/science/article/abs/pii/S0021929021000373?via%3Dihub
#speedbumps #pregnancy #fetus #uterus
speedbumps, pregnancy, fetus, uterus
CoVid Causes Brain Damage By Remote Control
Vidcast: https://youtu.be/ED4Ui26z0Uc
CoVid infections are associated with devastating brain damage without evidence that the virus itself infects brain tissue. Columbia University neuroscientists now publish these conclusions following their study of 41 consecutive deceased CoVid victims.
All had severe Covid disease with lung damage but only half required intubation. No viral particles or viral RNA were found in brain cells even in the olfactory bulb that mediates smell and taste. The cells showed signs of oxygen deprivation in association with blood clots, mini-strokes, and significant damage from immune inflammation but little evidence of killer T cell invasion.
The findings suggest brain damage as the result of remote hyperimmune cytotoxic storms.
https://academic.oup.com/brain/advance-article/doi/10.1093/brain/awab148/6226391
#CoVid #brain #stroke #cytotoxicstorm #hypoxia #inflammation
CoVid, brain, stroke, cytotoxicstorm, hypoxia, inflammation
Tell Me Why #Vaccine #Protection Isn’t Forever
Vidcast: https://youtu.be/C069WrAoDQ8
From TikTok viewer (user iii_1986_iii): Is it true that once you’re immune, you’re immune because if not that would make literally every vaccine ever manufactured worthless.
We all wish that were true. Even for# influenza, a yearly booster with different antigens is required. #Tetanus requires a 10 year booster. Even childhood vaccinations such as #MMR and #polio must be repeated if you are planning travel into an area where these diseases are present. All immunity wanes over time.
In the case of #Covid, the virus is mutating and the currently available vaccines made against the original strain are not completely protective. Boosters are now under development by Moderna and Pfizer.
If you have a Tell Me Why, ask it via my TikTok, YouTube, or Instagram channels or email me at drhowardsmith.reports@gmail.com.
==========================
Recalls
==========================
Playgro Clip Clop Infant Activity Rattle Is Recalled
Vidcast: https://youtu.be/pdfPMK8Plxo
The CPSC and Playgro are recalling the Playgro Clip Clop Infant Activity Rattle. The abacus ring on the horses back may dislodge, release small beads, and thereby create a choking hazard to small children. About 18,000 of these rattles have been sold nationwide at Walmart stores and on walmart.com. Take away these rattles from your children and contact Playgro at 1-855-775-2947 for a free replacement.
https://www.cpsc.gov/Recalls/2021/Playgro-Recalls-Infant-Activity-Rattles-Due-to-Choking-Hazard
#rattle #playgro #walmart #choking #recall
rattle, playgro, walmart, choking, recall
Recall On Cat & Back Baby Heart Ears Rompers
Vidcast: https://youtu.be/I12h9qDm-YE
The CPSC and Target now recall Cat & Back Baby Heart Ears Rompers. The heart-shaped decorations on the romper knees may peel off or detach and pose a choking hazard to children. About 44,350 of these garments were sold nationwide at Target stores and on target.com. Don’t permit your children to wear these rompers and return them to any Target store for a full refund. For additional information, contact Target by calling 1-800-440-0680.
https://www.cpsc.gov/Recalls/2021/Target-Recalls-Cat-Jack-Baby-Rompers-Due-to-Choking-Hazard
#romper #target #choking #recall
romper, target, choking, recall
Audio-Technica Wireless Headphone Charging Cases Are Recalled
Vidcast: https://youtu.be/SnBiPfdfCrU
The CPSC and Audio-Technica are recalling the Audio-Technica Wireless Headphone Charging Case Model ATH-CK3TW. These portable charging cases may overheat and create burn and fire hazards. About 7,450 units have been sold at American Musical Supply, Inmotion Entertainment Group, Micro Electronics, and Music and Arts Center stores as well as at other retailers nationwide and online at Amazon.com and audio-technica.com. Immediately stop using these charging cases and contact Audio-Technica at 1-800-518-2520 for instructions on returning the product for a free replacement charging case. Here’s how it works: Audio-Technica will send you a prepaid return shipping label. Once you return the case, the company will send you the replacement.
#chargingcase #audiotechnica #overheat #burn #recall
xchargingcase, audiotechnica, overheat, burn, recall
Recall On B. Toys Firefly Frank Infant Teethers
Vidcast: https://youtu.be/xGpKIwbEL6o
The CPSC and Battat recall B. Toys Firefly Frank Infant Teethers. Small plastic wings may detach from the teether’s body and create a choking hazard for young children. About 61,000 of these teethers were sold at Target and online at target.com, and about 210 were sold in Canada. Take these teethers away from your infant and toddlers and return them to any Target store for a refund. If you require additional information, call Battat at 844-963-2479.
#teether #battat #foreignbody #choking #recall
teether, battat, foreignbody, choking, recall
Torn & Glasser Dark Chocolate Expresso Beans On Recall
Vidcast: https://youtu.be/b6VW--bGwuM
The FDA and Torn and Glasser now recall Torn & Glasser Dark Chocolate Expresso Beans. This product is mislabeled and actually contains dark chocolate walnuts. Those with a walnut allergy could develop a severe or life-threatening reaction to ingesting this candy. The candy was sold by the Kroger conglomerate and variously branded as Kroger, Arlan’s, Fred Meyer, Smiths, Food For Less. Fry’s Food Stores, Ralphs, Dillons, Roundy’s Chicago, and Roundy’s Mariano’s. This product was sold in Alaska, Alabama, Arizona, Arkansas, California, Georgia, Illinois, Indiana, Idaho, Kansas, Kentucky, Louisiana, Michigan, Mississippi, Missouri, Montana, Nebraska, Nevada, New Mexico, Ohio, Oregon, South Carolina, Tennessee, Texas, Utah, Virginia, Washington, West Virginia, Wisconsin, Wyoming. Destroy the product and/or return it to the place of purchase for a full refund. Consumers with questions may contact the company at (213) 627-6496.
#walnuts #expressobeans #chocolate #kroger #recall
walnuts, expressobeans, chocolate, kroger, recall
Recall On Trader Joe’s Restaurant Style White Corn Tortilla Chips
Vidcast: https://youtu.be/Em_v2P-Y5j8
The FDA and Trader Joes now recall Trader Joe’s Restaurant Style White Corn Tortilla Chips. This product contains undisclosed milk making it dangerous for those with a milk allergy to ingest it. The product was sold in the following states: AL, AZ, AR, CA, CO, DC, DE, ID, KS, LA, MD, NJ, NM, NV, NY, OK, OR, PA, TN, TX, UT, VA, WA. If you bought these chips, return them to any Trader Joe’s store for a refund. For more information, contact Snak King Corporation at 1-626-363-7711.
#chips #milk #traderjoes #recall
chips, milk, traderjoes, recall
Panera at Home Lobster Bisque Recalled
Vidcast: https://youtu.be/SpN-R2CjHr0
The FDA and Blount Fine Foods are recalling Panera at Home Lobster Bisque. This soup contains an undeclared egg allergen. This product is only sold in supermarket refrigerated cases and not at Panera Bread restaurants. If you have this soup at home, don’t consume it. Call Blount Fine Foods at 1-866-674-4519 for additional information.
#lobsterbisque #soup #Panera #egg #recall
lobsterbisque, soup, Panera, egg, recall
Mr. Goodtime Chocolate Bunny Is Recalled
Vidcast: https://youtu.be/-2KhPu786jU
The FDA and Lake Champlain Chocolates are recalling the Mr. Goodtime Chocolate Bunny with a best by date of 11/20/2021. This product contains undeclared almonds. Those with almond allergies could develop a severe or life threatening allergic reaction after ingesting this candy. The bunny was sold in: CA, CT, MA, NH, NY, RI, TX, VT, and VA. If you purchased this product and have a known nut allergy, don’t consume the chocolate. Contact Lake Champlain Chocolates at 1-800-465-5909 to request a replacement.
#chocolate #bunny #almonds #allergy #recall
chocolate, bunny, almonds, allergy, recall
Recall On Durisan Hand Sanitizer
Vidcast: https://youtu.be/7uf1YfnNYsY
The FDA and Sanit Technologies are recalling Durisan Antimicrobial Hand Sanitizer, Non-Alcohol. This product is contaminated with the bacterium Burkholderia contaminans. Exposure to this product could cause an infection in a person with a hand wound or scrapes. The bacteria could enter the bloodstream in patients with compromised immune systems and cause sepsis. Don’t use this product and contact Durisan at 941-351-9114 to arrange for a refund.
#sanitizer #durisan #bacterium #sepsis
sanitizer, durisan, bacterium, sepsis
Bueno Coffee Substitute Is Recalled
Vidcast: https://youtu.be/O6T_AI-njN8
The FDA and Creative Foods Inc. now recall Bueno Coffee Substitute Creamy Hazelnut and Bueno Coffee Substitute Pecan Praline. Both products may contain undeclared peanut, hazelnut, and/or barley (gluten). Those with nut allergies may experience severe or lift-threatening allergic reactions after ingesting this product. Those with gluten intolerance or celiac disease may develop a severe gastrointestinal reaction. Those with such allergies should not consume this product but rather return it to the place of purchase for a refund. For more information, call Bueno Coffee at 1-541-788-2836.
#coffee #bueno #Peanut #hazelnut #gluten #celiac
coffee, bueno, Peanut, hazelnut, hazelnut, celiac
Raley’s Salt & Vinegar Flavored Potato Chips Are Recalled
Vidcast: https://youtu.be/Do2i-QOVXYQ
The FDA and Shearer’s Foods LLC have recalled Raley’s Salt & Vinegar Flavored Potato Chips. This product contains undeclared milk. Those with a milk allergy may develop a severe or life-threatening allergic reaction upon ingesting this product. Do not consume these potato chips but return them to the place of purchase for a refund. To obtain more information, reach Shearer’s Foods at 1-800-428-6843.
#potatochips #raleys #milk
potatochips, raleys, milk